The protein levels were assessed with enzyme-linked immunosorbent assay (ELISA) in serum of glioma patients, to further investigate their potential as non-invasive serum biomarkers. Kaplan–Meier survival analysis was also performed to test the prognostic utility of the proteins for glioma patients. ![]() Immunohistochemistry (IHC) and immunofluorescence (IF) in fixed tissue samples of glioma patients were used to evaluate the expression and localization of EGFR, MMP9, and MUC4. In this study, the role of MUC4, MMP9, and EGFR in the progression and clinical outcome of glioma patients was investigated. Interactions between mucin 4 (MUC4) and the epidermal growth factor receptor (EGFR) are involved in carcinogenesis, and may lead to matrix metalloproteinase-9 (MMP9) overexpression, exacerbating cancer cell invasiveness. There is therefore an urgent need for novel biomarkers and therapeutic targets. ![]() Glioblastoma is the most aggressive form of brain cancer, presenting poor prognosis despite current advances in treatment.
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